ADAM17
نویسندگان
چکیده
منابع مشابه
Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.
A disintegrin and metalloproteinase 17 (ADAM17) controls the release of the pro-inflammatory cytokine tumor necrosis factor α (TNFα, also known as TNF) and is crucial for protecting the skin and intestinal barrier by proteolytic activation of epidermal growth factor receptor (EGFR) ligands. The seven-membrane-spanning protein called inactive rhomboid 2 (Rhbdf2; also known as iRhom2) is required...
متن کاملEpidermal ADAM17 is dispensable for Notch activation
Animals The generation of Adam17 flox/flox Krt14-Cre, Egfr flox/flox Krt14-Cre and Adam10 flox/flox Krt14-Cre mice has been described previously (Franzke et al., 2012; Weber et al., 2011). All mice were of mixed genetic background (129Sv, C57BL/6), and all comparisons were between littermates. The mice were maintained in the Biomedical Research Center of the University Medical Center in Freibur...
متن کاملLeukocyte ADAM17 Regulates Acute Pulmonary Inflammation
The transmembrane protease ADAM17 regulates the release and density of various leukocyte cell surface proteins that modulate inflammation, including L-selectin, TNF-α, and IL-6R. At this time, its in vivo substrates and role in pulmonary inflammation have not been directly examined. Using conditional ADAM17 knock-out mice, we investigated leukocyte ADAM17 in acute lung inflammation. Alveolar TN...
متن کاملHow membrane asymmetry regulates ADAM17 sheddase function
Asymmetrical distribution of lipids in the cell membrane is a fundamental feature of all eukaryotic cells. The most important negatively charged phospholipids phosphatidylserine (PS) and phosphatidylinositol species reside almost exclusively in the cytoplasmic leaflet, where they serve as essential co-factors for many membrane-bound enzymes including protein kinase C, phosphatase PTEN, tyrosine...
متن کاملAdam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.
OBJECTIVE ADAM17 (a disintegrin and metalloproteinase 17) is a sheddase releasing different types of membrane-bound proteins, including adhesion molecules, cytokines, and their receptors as well as inflammatory mediators. Because these substrates modulate important mechanisms of atherosclerosis, we hypothesized that ADAM17 might be involved in the pathogenesis of this frequent disease. APPROA...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2017
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.116.308840